C-467929 is a Nsp15 endoribonuclease inhibitor with IC50 of 8 μM. C-467929 binds to SARS-CoV Nsp15 protein and can be used for infection studies.

Physicochemical Properties

Molecular Formula	C29H20N4O10
Molecular Weight	584.49
CAS #	351891-58-2
SMILES	C1=CC(=CC(=C1)[N+](=O)[O-])C(=O)NC2=C(C=C(C=C2)CC3=CC(=C(C=C3)NC(=O)C4=CC(=CC=C4)[N+](=O)[O-])C(=O)O)C(=O)O
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Small molecule inhibitors of the SARS-CoV Nsp15 endoribonuclease. Virus Adaptation and Treatment, September 2010 Volume 2010:2 Pages 125—133https://www.dovepress.com/small-molecule-inhibitors-of-the-sars-cov-nsp15-endoribonuclease-peer-reviewed-fulltext-article-VAAT.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.7109 mL	8.5545 mL	17.1089 mL
	5 mM	0.3422 mL	1.7109 mL	3.4218 mL
	10 mM	0.1711 mL	0.8554 mL	1.7109 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.