Bz-RS-iSer(3-Ph)-OMe (compound 2) is a paclitaxel analogue that can inhibit the HSV replication cycle with low cytotoxic effect, blocks mitosis of Vero cells, affects M-MSV-induced tumor size, and inhibits PHA induces T lymphocyte proliferation and affects immune response.

Physicochemical Properties

Molecular Formula	C17H17NO4
Molecular Weight	299.32
Exact Mass	299.115
CAS #	32981-85-4
PubChem CID	182104
Appearance	White to off-white solid powder
Density	1.2±0.1 g/cm3
Boiling Point	540.3±50.0 °C at 760 mmHg
Flash Point	280.6±30.1 °C
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.588
LogP	2.9
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	6
Heavy Atom Count	22
Complexity	373
Defined Atom Stereocenter Count	2
SMILES	O([H])C([H])(C(=O)OC([H])([H])[H])[C@]([H])(C1C([H])=C([H])C([H])=C([H])C=1[H])N([H])C(C1C([H])=C([H])C([H])=C([H])C=1[H])=O
InChi Key	UYJLJICUXJPKTB-LSDHHAIUSA-N
InChi Code	InChI=1S/C17H17NO4/c1-22-17(21)15(19)14(12-8-4-2-5-9-12)18-16(20)13-10-6-3-7-11-13/h2-11,14-15,19H,1H3,(H,18,20)/t14-,15+/m0/s1
Chemical Name	methyl (2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoate
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References	[1]. Krawczyk E, et al. Cytotoxic, antiviral (in-vitro and in-vivo), immunomodulatory activity and influence on mitotic divisions of three taxol derivatives: 10-deacetyl-baccatin III, methyl (N-benzoyl-(2'R,3'S)-3'-phenylisoserinate) and N-benzoyl-(2'R,3'S)-3'
Additional Infomation	Bz-RS-ISer(3-Ph)-Ome is a fatty acid ester.

Solubility Data

Solubility (In Vitro)

DMSO : 125 mg/mL (417.61 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.17 mg/mL (7.25 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 21.7 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.17 mg/mL (7.25 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 21.7 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.3409 mL	16.7045 mL	33.4091 mL
	5 mM	0.6682 mL	3.3409 mL	6.6818 mL
	10 mM	0.3341 mL	1.6705 mL	3.3409 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.