Bunamidine HCl is a veterinary anti-flatworm agent for Echinococcus granulosus and tapeworm tapeworms.

Physicochemical Properties

Molecular Formula	C25H39CLN2O
Molecular Weight	419.04
Exact Mass	418.275
Elemental Analysis	C, 71.66; H, 9.38; Cl, 8.46; N, 6.69; O, 3.82
CAS #	1055-55-6
Related CAS #	1055-55-6 (HCl);3748-77-4;
PubChem CID	13985
Appearance	Solid powder
Density	0.98g/cm3
Boiling Point	495ºC at 760mmHg
Flash Point	253.1ºC
Vapour Pressure	3.6E-11mmHg at 25°C
LogP	7.928
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	14
Heavy Atom Count	29
Complexity	417
Defined Atom Stereocenter Count	0
SMILES	Cl.CCCCCCOC1=CC=C(C(N(CCCC)CCCC)=N)C2=CC=CC=C12
InChi Key	PBYJDHRFPFHVKZ-UHFFFAOYSA-N
InChi Code	InChI=1S/C25H38N2O.ClH/c1-4-7-10-13-20-28-24-17-16-23(21-14-11-12-15-22(21)24)25(26)27(18-8-5-2)19-9-6-3;/h11-12,14-17,26H,4-10,13,18-20H2,1-3H3;1H
Chemical Name	1-Naphthalenecarboximidamide, N,N-dibutyl-4-(hexyloxy)-, monohydrochloride
Synonyms	Bunamidine hydrochloride; Bunamidine HCl; BW62415; BW-62415; BW 62415; Scolaban
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Gemmell MA, et al. Treatment of Echinococcus granulosus and Taenia hydatigena in dogs with bunamidine hydroxynaphthoate in a prepared food. Res Vet Sci. 1974;16(1):85-88.

Solubility Data

Solubility (In Vitro)

DMSO : 33.33 mg/mL (79.54 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 1.67 mg/mL (3.99 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 16.7 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 1.67 mg/mL (3.99 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 16.7 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 1.67 mg/mL (3.99 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 16.7 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.3864 mL	11.9320 mL	23.8641 mL
	5 mM	0.4773 mL	2.3864 mL	4.7728 mL
	10 mM	0.2386 mL	1.1932 mL	2.3864 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.