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Breast cancer targeting peptide 18–4 is a keratin 1 (KRT1) receptor targeting peptide with a Kd of 0.98 μM. The amino acid sequence of Breast cancer targeting peptide 18–4 is WxEAAYQrFL, which is a P160 peptide analog. Breast cancer targeting peptide 18–4 can significantly increase the uptake rate of MccJ25 in breast cancer cells and enhance its anticancer activity after covalent binding with the anticancer peptide MccJ25. The IC50 of this covalent conjugate against MCF-7, MDA-MB-435, and MDA-MB-435-MDR are 14.2, 20, and 25 μM, respectively.
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Physicochemical Properties
| Molecular Formula |
C63H89N15O15
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| Molecular Weight |
1296.47
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| CAS # |
1332850-08-4
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| Storage |
Powder-20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
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| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Biological Activity
| References |
[1]. Breast Cancer Targeting Peptide Binds Keratin 1: A New Molecular Marker for Targeted Drug Delivery to Breast Cancer. Mol Pharm. 2017 Mar 6;14(3):593-604.
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Solubility Data
| Preparing Stock Solutions |
|
1 mg |
5 mg |
10 mg |
| 1 mM |
0.7713 mL |
3.8566 mL |
7.7133 mL |
| 5 mM |
0.1543 mL |
0.7713 mL |
1.5427 mL |
| 10 mM |
0.0771 mL |
0.3857 mL |
0.7713 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles. |
