Physicochemical Properties
| Molecular Formula | C18H34 |
| Molecular Weight | 250.46256 |
| Exact Mass | 280.24 |
| CAS # | 2540-56-9 |
| PubChem CID | 5280644 |
| Appearance | Colorless to light yellow liquid |
| Density | 0.9±0.1 g/cm3 |
| Boiling Point | 381.6±11.0 °C at 760 mmHg |
| Flash Point | 278.5±14.4 °C |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.478 |
| LogP | 7.18 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 14 |
| Heavy Atom Count | 20 |
| Complexity | 267 |
| Defined Atom Stereocenter Count | 0 |
| SMILES | CCCCCC/C=C/C=C\CCCCCCCC(O)=O |
| InChi Key | JBYXPOFIGCOSSB-GOJKSUSPSA-N |
| InChi Code | InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-10H,2-6,11-17H2,1H3,(H,19,20)/b8-7+,10-9- |
| Chemical Name | (9Z,11E)-octadeca-9,11-dienoic acid |
| HS Tariff Code | 2934.99.9001 |
| Storage |
Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition | Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs) |
Biological Activity
| ln Vivo |
Bovinic acid (10E,12Z-conjugated linoleic acid, 10E,12Z-CLA) was detected in human adipose tissue, and its levels were positively correlated with milk fat intake [1] In dairy cows, dietary modifications (e.g., adjusting forage-to-concentrate ratio, supplementing with vegetable oils) increased the content of Bovinic acid in milk fat, a fatty acid beneficial to human health [2] |
| References |
[1]. Relation between the intake of milk fat and the occurrence of conjugated linoleic acid in human adipose tissue. Am J Clin Nutr. 1999 Jul;70(1):21-7. [2]. Modifying milk fat composition of dairy cows to enhance fatty acids beneficial to human health. Lipids. 2004 Dec;39(12):1197-206. |
| Additional Infomation |
9-cis,11-trans-octadecadienoic acid is an octadeca-9,11-dienoic acid having 9-cis,11-trans-stereochemistry. It is a conjugate acid of a 9-cis,11-trans-octadecadienoate. Bovinic acid has been reported in Skeletonema marinoi with data available. Conjugated Linoleic Acid is a slightly altered form of linoleic acid, which is an omega-6 fatty acid important to human health. It is found in beef and dairy fats. Bovinic acid is a naturally occurring isomer of conjugated linoleic acid (CLA), primarily found in milk fat and dairy products [1][2] Literature [1] conducted an epidemiological study involving human subjects: adipose tissue samples were collected, and Bovinic acid concentrations were quantified by gas chromatography; dietary intake data were obtained via food frequency questionnaires, revealing a positive correlation between milk fat consumption and adipose tissue Bovinic acid levels [1] Literature [2] focused on modifying dairy cow diets to enhance beneficial fatty acids in milk fat: different dietary regimens were applied to cows, milk samples were collected, and Bovinic acid content was analyzed by lipid extraction and chromatographic methods; results showed that dietary adjustments effectively increased Bovinic acid levels in milk [2] |
Solubility Data
| Solubility (In Vitro) | DMSO : ~100 mg/mL (~356.57 mM) |
| Solubility (In Vivo) |
Solubility in Formulation 1: 2.5 mg/mL (8.91 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 2: 20 mg/mL (71.31 mM) in 50% PEG300 50% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.9927 mL | 19.9633 mL | 39.9265 mL | |
| 5 mM | 0.7985 mL | 3.9927 mL | 7.9853 mL | |
| 10 mM | 0.3993 mL | 1.9963 mL | 3.9927 mL |