Bocidelpar is a peroxisome proliferator-activated receptor delta (PPAR-δ) modulator. In Duchenne Muscular Dystrophy (DMD) muscle cells, boidelpar enhances mitochondrial biogenesis and function (extracted from patent WO2017062468A1, compound 2b).

Physicochemical Properties

Molecular Formula	C25H27F3N2O3
Molecular Weight	460.488697290421
Exact Mass	460.197
Elemental Analysis	C, 65.21; H, 5.91; F, 12.38; N, 6.08; O, 10.42
CAS #	2095128-20-2
Related CAS #	2095128-20-2
PubChem CID	126752383
Appearance	Off-white to light yellow solid
Boiling Point	613.4±65.0 °C(Predicted)
LogP	5.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	10
Heavy Atom Count	33
Complexity	610
Defined Atom Stereocenter Count	1
SMILES	FC(C1C=CC(=CC=1)C1=NC=C(C)N1CC1C=CC=CC=1OCCC[C@@H](C)CC(=O)O)(F)F
InChi Key	FMOPHFSPINWSOV-QGZVFWFLSA-N
InChi Code	InChI=1S/C25H27F3N2O3/c1-17(14-23(31)32)6-5-13-33-22-8-4-3-7-20(22)16-30-18(2)15-29-24(30)19-9-11-21(12-10-19)25(26,27)28/h3-4,7-12,15,17H,5-6,13-14,16H2,1-2H3,(H,31,32)/t17-/m1/s1
Chemical Name	3R)-3-methyl-6-[2-[[5-methyl-2-[4-(trifluoromethyl)phenyl]imidazol-1-yl]methyl]phenoxy]hexanoic acid
Synonyms	MA-0211; MA 0211; MA0211; ASP0367; Bocidelpar
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	PPAR-δ
References	[1]. Ppar agonists, compounds, pharmaceutical compositions, and methods of use thereof. Patent WO2017062468A1.

Solubility Data

Solubility (In Vitro)

DMSO: ~250 mg/mL (~542.9 mM)

Solubility (In Vivo)

Solubility in Formulation 1: 2.08 mg/mL (4.52 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (4.52 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.1716 mL	10.8580 mL	21.7160 mL
	5 mM	0.4343 mL	2.1716 mL	4.3432 mL
	10 mM	0.2172 mL	1.0858 mL	2.1716 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.