Bfl-1-IN-6 (Compound 20) is an orally active Bcl-2-related protein A1 (BFL1) inhibitor with IC50 of 19 nM. Bfl-1-IN-6 can stabilize BFL1 protein, activate cleaved caspase 3, and exhibit antitumor activity in mouse models.

Physicochemical Properties

Molecular Formula	C22H24CLFN2O2
Molecular Weight	402.89
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Structure-Based Discovery of a Series of Covalent, Orally Bioavailable, and Selective BFL1 Inhibitors. J Med Chem. 2024 Dec 26;67(24):22055-22079.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.4821 mL	12.4103 mL	24.8207 mL
	5 mM	0.4964 mL	2.4821 mL	4.9641 mL
	10 mM	0.2482 mL	1.2410 mL	2.4821 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.