Benzoyleneurea possesses antimicrobial effect. Benzoyleneurea scaffolds are often used as inhibitors for the synthesis of novel PGGTase-I.

Physicochemical Properties

Molecular Formula	C8H6N2O2
Molecular Weight	162.14544
Exact Mass	162.042
CAS #	86-96-4
PubChem CID	64048
Appearance	Typically exists as solid at room temperature
Density	1.3±0.1 g/cm3
Boiling Point	491.9ºC at 760 mmHg
Melting Point	300 °C(lit.)
Index of Refraction	1.587
LogP	0.55
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	0
Heavy Atom Count	12
Complexity	227
Defined Atom Stereocenter Count	0
SMILES	O=C1NC2C(=CC=CC=2)C(=O)N1
InChi Key	SDQJTWBNWQABLE-UHFFFAOYSA-N
InChi Code	InChI=1S/C8H6N2O2/c11-7-5-3-1-2-4-6(5)9-8(12)10-7/h1-4H,(H2,9,10,11,12)
Chemical Name	1H-quinazoline-2,4-dione
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Additional Infomation

1H-Quinazoline-2,4-dione is a member of quinazolines. Benzoyleneurea has been reported in Streptomyces with data available.

Solubility Data

Solubility (In Vitro)

DMSO : ~43.33 mg/mL (~267.22 mM) H2O : < 0.1 mg/mL

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 3.25 mg/mL (20.04 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 32.5 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	6.1671 mL	30.8356 mL	61.6713 mL
	5 mM	1.2334 mL	6.1671 mL	12.3343 mL
	10 mM	0.6167 mL	3.0836 mL	6.1671 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.