BML-265 is a potent EGFR tyrosine kinase inhibitor. BML-265 disrupts the integrity of the Golgi apparatus and blocks the transport of secretory proteins to a variety of substances. BML-265 affects Golgi integrity and transport in human cells, but not in rodent cells.

Physicochemical Properties

Molecular Formula	C18H15N3O2
Molecular Weight	305.33
CAS #	183321-62-2
SMILES	C(C1C=CC=C(NC2C3=C(C=C(OC)C(OC)=C3)N=CN=2)C=1)#C
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. BML-265 and Tyrphostin AG1478 Disperse the Golgi Apparatus and Abolish Protein Transport in Human Cells. Front Cell Dev Biol. 2019 Oct 11;7:232.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.2751 mL	16.3757 mL	32.7514 mL
	5 mM	0.6550 mL	3.2751 mL	6.5503 mL
	10 mM	0.3275 mL	1.6376 mL	3.2751 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.