BG11 induces the accumulation of Fe2+ and intracellular lipid peroxides, inducing ferroptosis. BG11 regulates the expression of Bax and Bcl-2 proteins and induces apoptosis in MDA-MB-231 cells. BG11 arrests the cell cycle at G0/G1 and S phases, inhibits TNBC cancer cell proliferation (IC50 of MDA-MB-231 and BT549 are 0.49 μM and 0.52 μM, respectively), and inhibits cell migration and invasion. BG11 exhibits antitumor effects in mouse models.

Physicochemical Properties

Molecular Formula	C26H28CL2N6O2S
Molecular Weight	559.51
CAS #	3065877-52-0
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Discovery of novel JQ1 derivatives as dual ferroptosis and apoptosis inducers for the treatment of triple-negative breast cancer. Eur J Med Chem. 2025 Jan 11;286:117275.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.7873 mL	8.9364 mL	17.8728 mL
	5 mM	0.3575 mL	1.7873 mL	3.5746 mL
	10 mM	0.1787 mL	0.8936 mL	1.7873 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.