BCL-XL-IN-3 (Compound 11) is an inhibitor of BCL-XL with Ki < 0.01 nM. BCL-XL-IN-3 inhibits cell viability in normal Molt-4 and Digitonin-permeabilized Molt-4 with EC50 of 77.8 nM and 0.07 nM, respectively. BCL-XL-IN-3 can be used as an ADC toxin for the synthesis of Clezutoclax.

Physicochemical Properties

Molecular Formula	C46H55N7O6S
Molecular Weight	834.04
CAS #	1949840-87-2
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	BCLxL <0.01 nM (Ki)
References	[1]. BCL-XL-targeting antibody-drug conjugates are active in preclinical models and mitigate on-mechanism toxicity of small-molecule inhibitors. Sci Adv. 2024 Oct 4;10(40):eado7120.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.1990 mL	5.9949 mL	11.9898 mL
	5 mM	0.2398 mL	1.1990 mL	2.3980 mL
	10 mM	0.1199 mL	0.5995 mL	1.1990 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.