Azepexole hydrochloride (B-HT 933 dihydrochloride; Oxazoloazepin dihydrochloride) is a selective agonist of α 2-adrenoceptor, with pKi of 8.3, 7.6 and 7.5 for α2A-, α2B- and α2C- adrenoceptor subtypes, respectively. Azepexole dihydrochloride inhibits peristaltic contraction with an IC50 of 78.72 nM. Azepexole hydrochloride has antitussive and analgesic effects.

Physicochemical Properties

Molecular Formula	C9H16CLN3O
Molecular Weight	217.70
CAS #	147663-20-5
SMILES	Cl.O1C(N)=NC2=C1CCN(CC)CC2
Synonyms	B-HT 933 hydrochloride; Oxazoloazepin hydrochloride
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Specific role of α2A - and α2B -, but not α2C -, adrenoceptor subtypes in the inhibition of the vasopressor sympathetic out-flow in diabetic pithed rats. Basic Clin Pharmacol Toxicol. 2015;117(1):31-38. [2]. Capey S. AzepexoleJ. 2007.Pharm: The Comprehensive Pharmacology Reference.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	4.5935 mL	22.9674 mL	45.9348 mL
	5 mM	0.9187 mL	4.5935 mL	9.1870 mL
	10 mM	0.4593 mL	2.2967 mL	4.5935 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.