Arecoline, a pyridine alkaloid, is a potent corrector of GABA absorption. Arecoline is a substrate of H+-coupled amino acid (AA) transporter 1 (PAT1, SLC36A1) and antagonizes the nutrient inhibitory L-proline.

Physicochemical Properties

Molecular Formula	C7H11NO2
Molecular Weight	141.1677
Exact Mass	141.078
CAS #	499-04-7
Related CAS #	Arecaidine hydrochloride;6018-28-6;Arecaidine hydrobromide;6013-57-6
PubChem CID	10355
Appearance	White to off-white solid powder
Density	1.2±0.1 g/cm3
Boiling Point	266.7±35.0 °C at 760 mmHg
Melting Point	232ºC (dec.)
Flash Point	115.1±25.9 °C
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.524
LogP	0.77
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	1
Heavy Atom Count	10
Complexity	174
Defined Atom Stereocenter Count	0
InChi Key	DNJFTXKSFAMXQF-UHFFFAOYSA-N
InChi Code	InChI=1S/C7H11NO2/c1-8-4-2-3-6(5-8)7(9)10/h3H,2,4-5H2,1H3,(H,9,10)
Chemical Name	1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References	[1]. Effects of the Areca nut constituents arecaidine and guvacine on the action of GABA in the cat central nervous system. Brain Res. 1977 Nov 18;136(3):513-22. [2]. Transport of the areca nut alkaloid arecaidine by the human proton-coupled amino acid transporter 1 (hPAT1). J Pharm Pharmacol. 2013 Apr;65(4):582-90.
Additional Infomation	Arecaidine is a citraconoyl group. Arecaidine has been reported in Areca catechu with data available. See also: Arecaidine hydrochloride (annotation moved to).

Solubility Data

Solubility (In Vitro)	H2O : ~250 mg/mL (~1770.91 mM)
Solubility (In Vivo)	Solubility in Formulation 1: 100 mg/mL (708.37 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	7.0837 mL	35.4183 mL	70.8366 mL
	5 mM	1.4167 mL	7.0837 mL	14.1673 mL
	10 mM	0.7084 mL	3.5418 mL	7.0837 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.