Ar-V7-IN-1 is a potent Ar-V7 inhibitor. AR-V7 is a hormone-independent splice variant of the androgen receptor. Ar-V7-IN-1 may be used to be studied for a variety of indications, especially cancers like prostate cancer (information disclosed in patent WO2018114781A1, compound 43).

Physicochemical Properties

Molecular Formula	C10H10BR2N4OS
Molecular Weight	394.085598468781
Exact Mass	393.892
CAS #	2230880-25-6
PubChem CID	91754488
Appearance	White to off-white solid powder
LogP	3.2
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	2
Heavy Atom Count	18
Complexity	295
Defined Atom Stereocenter Count	0
SMILES	N1(C2=NC(N3C=NC(Br)=C3Br)=CS2)CCOCC1
InChi Key	KEFGZKYLWGZFFS-UHFFFAOYSA-N
InChi Code	InChI=1S/C10H10Br2N4OS/c11-8-9(12)16(6-13-8)7-5-18-10(14-7)15-1-3-17-4-2-15/h5-6H,1-4H2
Chemical Name	4-[4-(4,5-dibromoimidazol-1-yl)-1,3-thiazol-2-yl]morpholine
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Ar-v7 inhibitors. Patent WO2018114781A1.

Solubility Data

Solubility (In Vitro)

DMSO : ~83.33 mg/mL (~211.45 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.08 mg/mL (5.28 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (5.28 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.5375 mL	12.6875 mL	25.3749 mL
	5 mM	0.5075 mL	2.5375 mL	5.0750 mL
	10 mM	0.2537 mL	1.2687 mL	2.5375 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.