Antiviral agent 66 (Compound 60) is a filovirus inhibitor that inhibits pseudotyped viruses of Ebola, Marburg, Zaire, Sudan, Bundibugyo, Reston, and Tai Forest with EC50 values of 0.16, 2.24, 0.16, 0.89, 0.21, 0.21, and 0.11 μM, respectively.

Physicochemical Properties

Molecular Formula	C27H29F3N4O3
Molecular Weight	514.54
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Guardians at the Gate: Optimization of Small Molecule Entry Inhibitors of Ebola and Marburg Viruses. J Med Chem. 2025 Jan 9;68(1):135-155.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.9435 mL	9.7174 mL	19.4348 mL
	5 mM	0.3887 mL	1.9435 mL	3.8870 mL
	10 mM	0.1943 mL	0.9717 mL	1.9435 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.