Anti-Human/Rat HER2 (neu) Antibody (7.16.4) is a mouse-derived IgG2a, κ antibody inhibitor against human or rat HER2.

Physicochemical Properties

Molecular Weight	150000.00
Related CAS #	Cell-ATP Viability Detection Kit;Protein A Agarose;HOLO Human Interleukin-2 (IL-2) Detection Kit;Bradford Protein Assay Kit;Cell Counting Kit-8
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vitro

The antibody framework has stability, specificity and adaptability, and has the ability to bind antigens and endogenous immune receptors. Monoclonal antibodies have several derivatives, including bispecific antibodies, antibody-drug conjugates, and antibody fragments, which have shown remarkable effects in fields such as immunology and oncology. When designing inhibitory antibodies, attention should be paid to the identification of antigen-specific variable regions, the choice of expression system, the use of multispecific formats, and antibody derivatives based on fragmentation, oligomerization, or conjugation to other functional parts [1].

References

[1]. Goulet DR, Atkins WM. Considerations for the Design of Antibody-Based Therapeutics. J Pharm Sci. 2020 Jan;109(1):74-103.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	0.0067 mL	0.0333 mL	0.0667 mL
	5 mM	0.0013 mL	0.0067 mL	0.0133 mL
	10 mM	666.6667 nL	0.0033 mL	0.0067 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.