Ammonium bicarbonate, AR, 99%, is a bioactive chemical.

Physicochemical Properties

Molecular Formula	CH5NO3
Molecular Weight	79.06
Exact Mass	79.026
CAS #	1066-33-7
Related CAS #	10361-29-2;10361-29-2 (unspecified ammonium salt);40861-29-8 (ammonium-zinc salt)
PubChem CID	14013
Appearance	Colorless or white crystals Shiny, hard, colorless or white prisms or crystalline mass
Density	1,586 g/cm3
Boiling Point	169.8ºC
Melting Point	105 °C
Vapour Pressure	2.58E-05mmHg at 25°C
LogP	0.546
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	0
Heavy Atom Count	5
Complexity	24.8
Defined Atom Stereocenter Count	0
SMILES	O([H])C(=O)[O-].[N+]([H])([H])([H])[H]
InChi Key	ATRRKUHOCOJYRX-UHFFFAOYSA-N
InChi Code	InChI=1S/CH2O3.H3N/c2-1(3)4;/h(H2,2,3,4);1H3
Chemical Name	azanium;hydrogen carbonate
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ADME/Pharmacokinetics	Absorption, Distribution and Excretion There appears to be a more rapid excretion of ammonia following ammonium bicarbonate infusions, which result in higher unionized ammonia levels in blood compared, with those following ammonium chloride infusions. Metabolism / Metabolites Ammonium bicarbonate dissociated into free ammonia at level of cell membrane.
Toxicity/Toxicokinetics	Non-Human Toxicity Values LD50 Mouse iv 245 mg/kg
Additional Infomation	Ammonium bicarbonate appears as a white crystalline solid having the odor of ammonia. Soluble in water. The primary hazard is the threat to the environment. Immediate steps should be taken to limit spread to the environment. Used to make other ammonium compounds, in food processing, and for other uses. Ammonium bicarbonate is an organooxygen compound. Mechanism of Action Ammonium bicarbonate inhibits fungi because the bicarbonate anion supplies the alkalinity necessary to establish an antifungal concentration of free ammonia. Therapeutic Uses Antacid & stimulant. Dose 0.3-1 g. /Ammonium bicarbonate BP/ Medication (Vet): Expectorant, used in bloat, colic. Expectorant

Solubility Data

Solubility (In Vitro)

DMSO: 50 mg/mL (632.43 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (31.62 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (31.62 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.5 mg/mL (31.62 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	12.6486 mL	63.2431 mL	126.4862 mL
	5 mM	2.5297 mL	12.6486 mL	25.2972 mL
	10 mM	1.2649 mL	6.3243 mL	12.6486 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.