Amino-PEG3-C2-Amine is a PROTAC (PROteolysis TArgeting Chimera) linker (3 units), belonging to the Polyethylene glycol (PEG) category. Amino-PEG3-Amino may be utilized to prepare a veriety of PROTAC protein degraders.

Physicochemical Properties

Molecular Formula	C8H20N2O3
Molecular Weight	192.2560
Exact Mass	192.147
CAS #	929-75-9
PubChem CID	70250
Appearance	Colorless to light yellow liquid
Density	1.0±0.1 g/cm3
Boiling Point	291.1±25.0 °C at 760 mmHg
Flash Point	131.8±16.8 °C
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.462
LogP	-1.94
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	10
Heavy Atom Count	13
Complexity	83.5
Defined Atom Stereocenter Count	0
SMILES	O(CCOCCN)CCOCCN
InChi Key	NIQFAJBKEHPUAM-UHFFFAOYSA-N
InChi Code	InChI=1S/C8H20N2O3/c9-1-3-11-5-7-13-8-6-12-4-2-10/h1-10H2
Chemical Name	2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethanamine
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vitro	One ligand is for an E3 ubiquitin ligase, and the other is for the target protein; these two ligands are joined by a linker to form PROTACs. PROTACs target and selectively degrade target proteins by taking advantage of the intracellular ubiquitin-proteasome system.
References	[1]. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67.

Solubility Data

Solubility (In Vitro)	H2O : ~100 mg/mL (~520.13 mM)
Solubility (In Vivo)	Solubility in Formulation 1: 100 mg/mL (520.13 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	5.2013 mL	26.0064 mL	52.0129 mL
	5 mM	1.0403 mL	5.2013 mL	10.4026 mL
	10 mM	0.5201 mL	2.6006 mL	5.2013 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.