Adhibin is an allosteric inhibitor of RhoGAP class IX myosin, which inhibits Myo9 ATPase in mammals and invertebrates with IC50 of 2.5 µM and 2.6 µM, respectively. Adhibin binds to ATPase, interferes with the motor function of myosin, blocks RhoGTPase-related signaling pathways, and affects cell migration, adhesion, and cell division. Adhibin can be used for cancer metastasis research.

Physicochemical Properties

Molecular Formula	C13H9BR2NO
Molecular Weight	355.02
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. An allosteric inhibitor of RhoGAP class-IX myosins suppresses the metastatic features of cancer cells. Nat Commun. 2024 Nov 16;15(1):9947.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.8167 mL	14.0837 mL	28.1674 mL
	5 mM	0.5633 mL	2.8167 mL	5.6335 mL
	10 mM	0.2817 mL	1.4084 mL	2.8167 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.