Acetyl-PHF6 amide TFA (AcPHF6 TFA) is a tau-derived hexapeptide.

Physicochemical Properties

Molecular Formula	C40H64F3N9O11
Molecular Weight	903.99
Appearance	Typically exists as solid at room temperature
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Tau Derived Hexapeptide AcPHF6 Promotes Beta-Amyloid (Aβ) Fibrillogenesis. ACS Chem Neurosci. 2018 Apr 18;9(4):773-782.

Solubility Data

Solubility (In Vitro)

DMSO :~67.5 mg/mL (~74.67 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.25 mg/mL (2.49 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 22.5 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.1062 mL	5.5310 mL	11.0621 mL
	5 mM	0.2212 mL	1.1062 mL	2.2124 mL
	10 mM	0.1106 mL	0.5531 mL	1.1062 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.