Ac2-26 TFA, the active N-terminal peptide of annexin A1 (AnxA1), alleviates ischemia-reperfusion-induced acute lung injury. Ac2-26 also reduces AnxA1 protein expression and inhibits the activation of NF-κB and MAPK pathways in damaged lung tissue.

Physicochemical Properties

Molecular Formula	C143H211F3N32O46S
Molecular Weight	3203.45
Related CAS #	Ac2-26;151988-33-9;Ac2-26 ammonium
Appearance	White to off-white solid powder
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Ac2-26, an Annexin A1 Peptide, Attenuates Ischemia-Reperfusion-Induced Acute Lung Injury. Int J Mol Sci. 2017 Aug 15;18(8). pii: E1771.

Solubility Data

Solubility (In Vitro)	DMSO :~50 mg/mL (~15.61 mM) H2O :~1.93 mg/mL (~0.60 mM)
Solubility (In Vivo)	Solubility in Formulation 1: 1 mg/mL (0.31 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	0.3122 mL	1.5608 mL	3.1216 mL
	5 mM	0.0624 mL	0.3122 mL	0.6243 mL
	10 mM	0.0312 mL	0.1561 mL	0.3122 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.