Physicochemical Properties
| Molecular Formula | C33H40O7S |
| CAS # | 2690312-65-1 |
| Appearance | White to off-white solid powder |
| HS Tariff Code | 2934.99.9001 |
| Storage |
Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition | Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs) |
Biological Activity
| ln Vitro | ASR-488 (0.2-12.5 µM, 24-72 h) has the ability to drastically suppress the development of HT1376 and TCCSUP cells and successfully generate apoptotic signals [1]. |
| Cell Assay |
Cell Proliferation Assay[1] Cell Types: BCa cell lines TCCSUP and HT1376 Tested Concentrations: 0.2-12.5 µM Incubation Duration: 24, 48 and 72 h Experimental Results: demonstrated that the IC 50 of TCCSUP was 800, 480 and 450 nM at different time periods of 24, 48 and 72 hrs (hours), and the IC 50 of HT1376 was 1.28 µM, 750 and 850 nM, respectively. Caused a downregulation of p65 and Bcl-2 expression and a marked increase in apoptosis in TCCSUP and HT1376 cells. |
| References |
[1]. ASR488, a novel small molecule, activates an mRNA binding protein, CPEB1, and inhibits the growth of bladder cancer. Oncol Lett. 2020 Jul;20(1):850-860. |
Solubility Data
| Solubility (In Vitro) | DMSO : 100 mg/mL (172.20 mM) |
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (4.30 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (4.30 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |