ART899 is a highly specific allosteric inhibitor of the Polθ DNA polymerase domain. ART899 can effectively enhance the radiosensitivity of tumor cells, is well tolerated in combination with fractionated radiation, and can significantly reduce tumor growth compared with radiation alone.

Physicochemical Properties

Molecular Formula	C19H13D3CLF4N3O4
Molecular Weight	464.81
CAS #	2607139-85-3
Related CAS #	ART812;2607138-82-7
SMILES	ClC1=C(C=CC(=C1)N(C([2H])([2H])[2H])C([C@@H]1[C@@H]([C@@H](C(N1C1C=C(C(F)(F)F)C=C(C)N=1)=O)O)O)=O)F
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models. Clin Cancer Res. 2023 Apr 14;29(8):1631-1642.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.1514 mL	10.7571 mL	21.5142 mL
	5 mM	0.4303 mL	2.1514 mL	4.3028 mL
	10 mM	0.2151 mL	1.0757 mL	2.1514 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.