 Chemical Structure.png)
Physicochemical Properties
| Molecular Formula | C14H11N3O4 |
| Molecular Weight | 285.25 |
| Exact Mass | 315.073 |
| CAS # | 148757-94-2 |
| PubChem CID | 2762553 |
| Appearance | Off-white to yellow solid powder |
| Boiling Point | 661.0±65.0 °C at 760 mmHg |
| Flash Point | 353.5±34.3 °C |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| LogP | -1.98 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 3 |
| Heavy Atom Count | 21 |
| Complexity | 438 |
| Defined Atom Stereocenter Count | 0 |
| InChi Key | LINZYZMEBMKKIT-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C14H11N3O4/c18-12-5-6-13(19)17(12)21-14(20)16-10-3-4-11-9(8-10)2-1-7-15-11/h1-4,7-8H,5-6H2,(H,16,20) |
| Chemical Name | (2,5-dioxopyrrolidin-1-yl) N-quinolin-6-ylcarbamate |
| HS Tariff Code | 2934.99.9001 |
| Storage |
Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition | Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs) |
Biological Activity
| ln Vitro | Many of the drawbacks associated with other deriving reagents are overcome when using AQC (6-Aminoquinolyl-N-hydroxysccinimidyl carbamate), which reacts with primary and secondary amino acids to yield fluorescent derivates (λ excitation and emission at 250 and 395 nm, respectively). This allows amino acid detection at under-picomolar levels. |
| References |
[1]. Application of the 6-aminoquinolyl-N-hydroxysccinimidyl carbamate (AQC) reagent to the RP-HPLC determination of amino acids in infant foods. J Chromatogr B Analyt Technol Biomed Life Sci. 2006;831(1-2):176-183. [2]. Applications of amino acid derivatization with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate. Analysis of feed grains, intravenous solutions and glycoproteins. J Chromatogr A. 1994;661(1-2):25-34. |
Solubility Data
| Solubility (In Vitro) | DMSO: 100 mg/mL (350.57 mM) |
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (8.76 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (8.76 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.5 mg/mL (8.76 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.5057 mL | 17.5285 mL | 35.0570 mL | |
| 5 mM | 0.7011 mL | 3.5057 mL | 7.0114 mL | |
| 10 mM | 0.3506 mL | 1.7528 mL | 3.5057 mL |