APL-1092 (Mal-Exo-EEVC-Exatecan) is a drug-linker conjugate that can be used for ADC synthesis. Its structure contains Exatecan (ADC payload) and linker.

Physicochemical Properties

Molecular Formula	C65H77FN12O19
Molecular Weight	1349.37
CAS #	2921735-91-1
Synonyms	Mal-Exo-EEVC-Exatecan
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Exo-Cleavable Linkers: Enhanced Stability and Therapeutic Efficacy in Antibody-Drug Conjugates. J Med Chem. 2024 Oct 24;67(20):18124-18138.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	0.7411 mL	3.7054 mL	7.4109 mL
	5 mM	0.1482 mL	0.7411 mL	1.4822 mL
	10 mM	0.0741 mL	0.3705 mL	0.7411 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.