APL-1081 (Mal-Exo-EVC-MMAE) is part of an antibody-conjugated active molecule ADC. APL-1081 is conjugated with ADC linker (peptide Mal-Exo-EEVC) and MMAE, a potent tubulin polymerization inhibitor.

Physicochemical Properties

Molecular Formula	C75H115N13O19
Molecular Weight	1502.79
CAS #	2921735-80-8
Appearance	White to off-white solid powder
Synonyms	Mal-Exo-EVC-MMAE
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Exo-Cleavable Linkers: Enhanced Stability and Therapeutic Efficacy in Antibody–Drug ConjugatesJ. Journal of Medicinal Chemistry, 2024.

Solubility Data

Solubility (In Vitro)

DMSO : ~100 mg/mL (~66.54 mM; with ultrasonication)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	0.6654 mL	3.3271 mL	6.6543 mL
	5 mM	0.1331 mL	0.6654 mL	1.3309 mL
	10 mM	0.0665 mL	0.3327 mL	0.6654 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.