AP39 prodrug 1 (Compound M1) is a mitochondria-targeted H2S prodrug. AP39 prodrug 1 induces ROS-dependent mild mitochondrial uncoupling in hepatocytes, activates mitochondria-associated AMPK, and inhibits palmitic acid (PA)-induced lipid deposition.

Physicochemical Properties

Molecular Formula	C53H51BRNO10PS
Molecular Weight	1004.92
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. A Spatiotemporally Controlled and Mitochondria-Targeted Prodrug of Hydrogen Sulfide Enables Mild Mitochondrial Uncoupling for the Prevention of Lipid Deposition. J Med Chem. 2024 Nov 14;67(21):19188-19199.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	0.9951 mL	4.9755 mL	9.9510 mL
	5 mM	0.1990 mL	0.9951 mL	1.9902 mL
	10 mM	0.0995 mL	0.4976 mL	0.9951 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.