AMPK-IN-6 (compound 13a) is a potent AMPK inhibitor with IC50 of 0.093 µM. AMPK-IN-6 induces apoptosis and inhibits autophagy. AMPK-IN-6 has antiproliferative activity. AMPK-IN-6 has the potential to study pulmonary hypertension.

Physicochemical Properties

Molecular Formula	C18H20FN5O
Molecular Weight	341.38
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	AMPK 0.093 μM (IC50)
References	[1]. A novel pyridine-2-one AMPK inhibitor: Discovery, mechanism, and in vivo evaluation in a hypoxic pulmonary arterial hypertension rat model. Eur J Med Chem. 2025 Jan 12;286:117266.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.9293 mL	14.6464 mL	29.2929 mL
	5 mM	0.5859 mL	2.9293 mL	5.8586 mL
	10 mM	0.2929 mL	1.4646 mL	2.9293 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.