ALK5-IN-84 (Compound 23) is an ALK5 inhibitor with a pki value of 9.35 for hALK5. ALK5-IN-84 can exert its significant ALK5 inhibitory activity when administered by inhalation. ALK5-IN-84 is expected to be used in the development of inhaled ALK5 inhibitors.

Physicochemical Properties

Molecular Formula	C20H20CLFN6O
Molecular Weight	414.86
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Design, Synthesis, and Activity of a Novel Series of Pyridazine-Based ALK5 Inhibitors. ACS Med Chem Lett. 2024 Oct 23;15(11):1925-1932.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.4105 mL	12.0523 mL	24.1045 mL
	5 mM	0.4821 mL	2.4105 mL	4.8209 mL
	10 mM	0.2410 mL	1.2052 mL	2.4105 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.