AHL-Pu-2 is a clickable electrophilic purine. AHL-Pu-2 directly quantifies protein-RNA interactions on proteins through photoaffinity competition with 4-thiouridine (4SU)-labeled RNA in cells.

Physicochemical Properties

Molecular Formula	C8H4CL2N4
Molecular Weight	227.05
CAS #	1838570-66-3
SMILES	ClC1C2=C(N=C(N=1)Cl)N=CN2CC#C
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	4.4043 mL	22.0216 mL	44.0432 mL
	5 mM	0.8809 mL	4.4043 mL	8.8086 mL
	10 mM	0.4404 mL	2.2022 mL	4.4043 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.