Physicochemical Properties
| Storage |
Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition | Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs) |
Biological Activity
| ln Vivo | ABBV-154 (ADC 11) (0-80 mg/kg; subcutaneous injection; once every two weeks; 13 weeks) showed good stability in cynomolgus monkeys, with a stable DAR of 4.0[1]. |
| References |
[1]. Discovery of ABBV-154, an anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody-Drug Conjugate (iADC). J Med Chem. 2023 Sep 14;66(17):12544-12558. |