9-Octadecynoic acid is a DNA-binding agent with a dissociation constant of 1.8 mM. 9-Octadecynoic acid is also an agonist of peroxisome proliferator-activated receptor gamma (PPARγ).

Physicochemical Properties

Molecular Formula	C18H32O2
Molecular Weight	280.45
CAS #	506-24-1
Appearance	White to off-white solid powder
SMILES	CCCCCCCCC#CCCCCCCCC(=O)O
Synonyms	Stearyl Acid
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. 9-Octadecynoic acid: a novel DNA binding agent. Chem Res Toxicol. 1991 Mar-Apr;4(2):195-8. [2]. Identification of 6-octadecynoic acid from a methanol extract of Marrubium vulgare L. as a peroxisome proliferator-activated receptor γ agonist. Biochem Biophys Res Commun. 2013 Oct 18;440(2):204-9.

Solubility Data

Solubility (In Vitro)

DMSO : ~200 mg/mL (~713.14 mM; with ultrasonication)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 5 mg/mL (17.83 mM)(saturation unknown) in 10% DMSO 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one),clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 50.0 mg/mL clear DMSO stock solution and add it to 900 μL corn oil and mix well.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.5657 mL	17.8285 mL	35.6570 mL
	5 mM	0.7131 mL	3.5657 mL	7.1314 mL
	10 mM	0.3566 mL	1.7828 mL	3.5657 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.