9-Ethyladenine is a partially effective inhibitor of APRT (adenine phosphoribosyltransferase).

Physicochemical Properties

Molecular Formula	C7H9N5
Molecular Weight	163.18
Exact Mass	163.085
CAS #	2715-68-6
PubChem CID	7
Appearance	White to off-white solid powder
Density	1.5±0.1 g/cm3
Boiling Point	382.2±45.0 °C at 760 mmHg
Melting Point	196.5-197.5 °C(benzene)
Flash Point	185.0±28.7 °C
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.753
LogP	0.26
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	1
Heavy Atom Count	12
Complexity	162
Defined Atom Stereocenter Count	0
InChi Key	MUIPLRMGAXZWSQ-UHFFFAOYSA-N
InChi Code	InChI=1S/C7H9N5/c1-2-12-4-11-5-6(8)9-3-10-7(5)12/h3-4H,2H2,1H3,(H2,8,9,10)
Chemical Name	Adenine, 9-ethyl- (8CI)
Synonyms	9-Ethyladenine NSC-14580 NSC14580NSC 14580
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. No self-injurious behavior was found in HPRT-deficient mice treated with 9-ethyladenine. Pharmacol Biochem Behav. 1998 Oct;61(2):175-9.

Solubility Data

Solubility (In Vitro)

H2O : ~100 mg/mL (~612.82 mM) DMSO : ~62.5 mg/mL (~383.01 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 3 mg/mL (18.38 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 30.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 3 mg/mL (18.38 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 30.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 3 mg/mL (18.38 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 30.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. Solubility in Formulation 4: 33.33 mg/mL (204.25 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	6.1282 mL	30.6410 mL	61.2820 mL
	5 mM	1.2256 mL	6.1282 mL	12.2564 mL
	10 mM	0.6128 mL	3.0641 mL	6.1282 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.