7-Methyl-guanosine-5'-triphosphate (m7GTP) disodium is a guanosine 5'-phosphate. The phosphorothioate analog of 7-Methyl-guanosine-5'-triphosphate disodium is a potent cap-dependent inhibitor of translation.

Physicochemical Properties

Molecular Formula	C11H16N5NA2O14P3
Molecular Weight	581.17
CAS #	104809-18-9
SMILES	N1(C(C)NC2C(=O)NC=NC1=2)[C@H]1[C@H](O)[C@H](O)[C@@H](COP(=O)(O)OP(=O)(O)OP([O-])(=O)O)O1.[Na+]
Synonyms	m7GTP disodium
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Phosphorothioate analogs of m7GTP are enzymatically stable inhibitors of cap-dependent translation. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1921-5.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.7207 mL	8.6033 mL	17.2067 mL
	5 mM	0.3441 mL	1.7207 mL	3.4413 mL
	10 mM	0.1721 mL	0.8603 mL	1.7207 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.