7-Acetyl paclitaxel is a microtubule depolymerization inhibitor that inhibits calcium-induced microtubule depolymerization. 7-Acetyl paclitaxel reduces the growth of J774.2 macrophages (IC50 ~ 60 nM) and increases nitric oxide (NO) and TNF levels in isolated mouse peritoneal macrophages.

Physicochemical Properties

Molecular Formula	C49H53NO15
Molecular Weight	895.94
CAS #	92950-39-5
SMILES	O([C@@]12CO[C@@H]1C[C@H](OC(=O)C)[C@]1(C([C@@H](C3=C(C)[C@@H](OC(=O)[C@H](O)[C@H](C4C=CC=CC=4)NC(C4C=CC=CC=4)=O)C[C@]([C@H]([C@H]21)OC(C1C=CC=CC=1)=O)(O)C3(C)C)OC(=O)C)=O)C)C(=O)C
Synonyms	7-Acetylpaclitaxel
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Structure-activity relationship study of taxoids for their ability to activate murine macrophages as well as inhibit the growth of macrophage-like cells. Bioorg Med Chem. 2003 Jul 3;11(13):2867-88.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.1161 mL	5.5807 mL	11.1615 mL
	5 mM	0.2232 mL	1.1161 mL	2.2323 mL
	10 mM	0.1116 mL	0.5581 mL	1.1161 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.