6-Methoxyflavanone (6-MeOF) is an orally active flavonoid. 6-Methoxyflavanone has anxiolytic effects. Unlike traditional benzodiazepines, 6-Methoxyflavanone acts on GABA-A receptors. 6-Methoxyflavanone can be used to study anxiety disorders. 6-Methoxyflavanone readily crosses the blood-brain barrier (BBB).

Physicochemical Properties

Molecular Formula	C16H14O3
Molecular Weight	254.28
CAS #	3034-04-6
PubChem CID	97860
Appearance	Off-white to light yellow solid powder
Density	1.199g/cm3
Boiling Point	425.5ºC at 760mmHg
Melting Point	141-143 °C(lit.)
Flash Point	202.9ºC
Index of Refraction	1.587
LogP	3.402
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	2
Heavy Atom Count	19
Complexity	322
Defined Atom Stereocenter Count	0
SMILES	COC1=CC2=C(C=C1)OC(CC2=O)C3=CC=CC=C3
Synonyms	6-MeOF
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Characterization of 6-methoxyflavanone as a novel anxiolytic agent: A behavioral and pharmacokinetic approach. Eur J Pharmacol. 2017 Apr 15;801:19-27.

Solubility Data

Solubility (In Vitro)

DMSO : ~100 mg/mL (~393.27 mM; with ultrasonication)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (9.83 mM)(saturation unknown) in 10% DMSO 40% PEG300 5% Tween-80 45% Saline (add these co-solvents sequentially from left to right, and one by one),clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution and add it to 400 μL PEG300, mix well; then add 50 μL Tween-80 to the above system, mix well; then continue to add 450 μL of normal saline to make up to 1 mL. Preparation of normal saline: Dissolve 0.9 g of sodium chloride in ddH₂O and make up to 100 mL to obtain a clear and transparent normal saline solution.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.9327 mL	19.6634 mL	39.3267 mL
	5 mM	0.7865 mL	3.9327 mL	7.8653 mL
	10 mM	0.3933 mL	1.9663 mL	3.9327 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.