6-Dimethylaminopurine is a novel and potent serine threonine protein kinase inhibitor which inhibits the germinal vesicle breakdown and the meiotic maturation of oocytes.
Physicochemical Properties
| Molecular Formula | C7H9N5 |
| Molecular Weight | 163.1799 |
| Exact Mass | 163.085 |
| Elemental Analysis | C, 51.52; H, 5.56; N, 42.92 |
| CAS # | 938-55-6 |
| Related CAS # | 938-55-6 |
| PubChem CID | 3134 |
| Appearance | White to off-white solid powder |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 427.4±25.0 °C at 760 mmHg |
| Melting Point | 259-262 °C(lit.) |
| Flash Point | 212.3±23.2 °C |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.718 |
| LogP | 1.43 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 1 |
| Heavy Atom Count | 12 |
| Complexity | 160 |
| Defined Atom Stereocenter Count | 0 |
| SMILES | N1C2=C(NC=N2)C(N(C)C)=NC=1 |
| InChi Key | BVIAOQMSVZHOJM-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C7H9N5/c1-12(2)7-5-6(9-3-8-5)10-4-11-7/h3-4H,1-2H3,(H,8,9,10,11) |
| Chemical Name | N,N-dimethyl-7H-purin-6-amine |
| Synonyms | N(6),N(6)-Dimethyladenine; 6-Dimethylaminopurine; NSC 401568; NSC401568; NSC-401568 |
| HS Tariff Code | 2934.99.9001 |
| Storage |
Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition | Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs) |
Biological Activity
| References |
[1]. 6-Dimethylaminopurine blocks starfish oocyte maturation by inhibiting a relevant protein kinase activity. Exp Cell Res. 1988 May;176(1):68-79. [2]. Properties and potential-applications of chemical inhibitors of cyclin-dependent kinases. Pharmacol Ther. 1999 May-Jun;82(2-3):279-84. |
| Additional Infomation |
N(6),N(6)-dimethyladenine is a tertiary amine that is adenine substituted at N-6 by geminal methyl groups. It is functionally related to an adenine. 6-Dimethylaminopurine has been reported in Spiraea formosana with data available. |
Solubility Data
| Solubility (In Vitro) | DMSO: 32~41.7 mg/mL (196.1~255.4 mM) |
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (12.75 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (12.75 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.08 mg/mL (12.75 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.1282 mL | 30.6410 mL | 61.2820 mL | |
| 5 mM | 1.2256 mL | 6.1282 mL | 12.2564 mL | |
| 10 mM | 0.6128 mL | 3.0641 mL | 6.1282 mL |