6-Chloro-1-hexanol is a biochemical compound that may be utilized as a biomaterial or organic/chemical reagent for biomedical research.

Physicochemical Properties

Molecular Formula	C6H13CLO
Molecular Weight	136.62
Exact Mass	136.065
CAS #	2009-83-8
Related CAS #	6-Chloro-1-hexanol-d6;1219794-83-8
PubChem CID	74828
Appearance	Colorless to light yellow liquid（Density：1.024 g/cm3）
Density	1.0±0.1 g/cm3
Boiling Point	212.8±0.0 °C at 760 mmHg
Melting Point	129-130ºC
Flash Point	98.9±0.0 °C
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.444
LogP	1.62
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	5
Heavy Atom Count	8
Complexity	39.5
Defined Atom Stereocenter Count	0
SMILES	ClC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])O[H]
InChi Key	JNTPTNNCGDAGEJ-UHFFFAOYSA-N
InChi Code	InChI=1S/C6H13ClO/c7-5-3-1-2-4-6-8/h8H,1-6H2
Chemical Name	6-chlorohexan-1-ol
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vitro

6-Chloro-1-hexanol is prepared by reacting it with sodium bromide in the presence of N,N-dimethylformamide and dibromomethane (2:1) as solvents. It is employed in the selective removal of 6-chloro-1-hexene from the ester of 6-chloro-1-hexanol.

Solubility Data

Solubility (In Vitro)

DMSO: 100 mg/mL (731.96 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (18.30 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (18.30 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.5 mg/mL (18.30 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	7.3196 mL	36.5979 mL	73.1957 mL
	5 mM	1.4639 mL	7.3196 mL	14.6391 mL
	10 mM	0.7320 mL	3.6598 mL	7.3196 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.