6-B345TTQ is an α4 integrin inhibitor that inhibits α4-Leupaxin interaction. 6-B345TTQ can be used in inflammation research.

Physicochemical Properties

Molecular Formula	C22H20BRNO4
Molecular Weight	442.30
CAS #	297157-87-0
SMILES	COC1=C(OC)C=C(C2CC(=O)NC3C4=CC=CC=C4C(=CC2=3)Br)C=C1OC
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. A small molecule that inhibits the interaction of paxillin and alpha 4 integrin inhibits accumulation of mononuclear leukocytes at a site of inflammation. J Biol Chem. 2010 Mar 26;285(13):9462-9469.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.2609 mL	11.3045 mL	22.6091 mL
	5 mM	0.4522 mL	2.2609 mL	4.5218 mL
	10 mM	0.2261 mL	1.1305 mL	2.2609 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.