5-Vinyl-2'-deoxyuridine (5-VINYL-DURD) is a thymidine analog that is incorporated into cellular DNA during DNA replication. 5-Vinyl-2'-deoxyuridine is a click chemistry reagent that contains an alkyne group and induces DNA damage leading to apoptosis in cultured human cells.

Physicochemical Properties

Molecular Formula	C11H14N2O5
Molecular Weight	254.24
CAS #	55520-67-7
Appearance	Solid powder
SMILES	C=CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)O
Synonyms	5-VINYL-DURD
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. DNA templated Click Chemistry via 5-vinyl-2'-deoxyuridine and an acridine-tetrazine conjugate induces DNA damage and apoptosis in cancer cells. Life Sci. 2023 Oct 1:330:122000.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.9333 mL	19.6665 mL	39.3329 mL
	5 mM	0.7867 mL	3.9333 mL	7.8666 mL
	10 mM	0.3933 mL	1.9666 mL	3.9333 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.