3-Pyridinemethanol (Nicotinyl alcohol), a pyridine analogue, is a cholesterol-lowering agent.

Physicochemical Properties

Molecular Formula	C6H7NO
Molecular Weight	109.13
Exact Mass	109.052
CAS #	100-55-0
PubChem CID	7510
Appearance	Light yellow to light brown liquid（Density：1.124 g/cm3）
Density	1.1±0.1 g/cm3
Boiling Point	266.0±0.0 °C at 760 mmHg
Melting Point	-7 °C
Flash Point	97.5±20.4 °C
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.551
LogP	-0.46
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	1
Heavy Atom Count	8
Complexity	65.5
Defined Atom Stereocenter Count	0
SMILES	OCC1=CC=CN=C1
InChi Key	MVQVNTPHUGQQHK-UHFFFAOYSA-N
InChi Code	InChI=1S/C6H7NO/c8-5-6-2-1-3-7-4-6/h1-4,8H,5H2
Chemical Name	pyridin-3-ylmethanol
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Heiberg A. Nikotinyl-alkohol som kolesterolsenkende medikament [Nicotinyl alcohol as a cholesterol-lowering agent]. Nord Med. 1969;81(22):698-700. [2]. Gargaun S, et al. A novel method aimed at counteracting the side effects caused by prostaglandin e2 deficiency during non-steroidal anti-inflammatory drug therapy. Antiinflamm Antiallergy Agents Med Chem. 2014;13(2):121-127.

Additional Infomation

3-pyridinemethanol is a member of the class of pyridines that is pyridine which is substituted by a hydroxymethyl group at position 3. It has a role as a vasodilator agent and an antilipemic drug. It is a member of pyridines and an aromatic primary alcohol. 3-Pyridinemethanol has been reported in Crocus sativus and Nicotiana tabacum with data available. Alcohol analog of NICOTINIC ACID which is a direct-acting peripheral vasodilator that causes flushing and may decrease blood pressure. It is used in vasospasm and threatened GANGRENE.

Solubility Data

Solubility (In Vitro)

DMSO: 100 mg/mL (916.34 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (22.91 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (22.91 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.5 mg/mL (22.91 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	9.1634 mL	45.8169 mL	91.6338 mL
	5 mM	1.8327 mL	9.1634 mL	18.3268 mL
	10 mM	0.9163 mL	4.5817 mL	9.1634 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.