Physicochemical Properties
| Molecular Formula | C4H7NAO3 |
| Molecular Weight | 126.09 |
| CAS # | 150-83-4 |
| Related CAS # | 3-Hydroxybutyric acid-13C4 sodium,3-Hydroxybutyric acid,3-Hydroxybutyric acid-d2 sodium,3-Hydroxybutyric acid-13C2 sodium |
| Appearance | White to off-white solid powder |
| Boiling Point | 269.2ºC at 760mmHg |
| Melting Point | 165-167ºC |
| Flash Point | 121ºC |
| Vapour Pressure | 0.000979mmHg at 25°C |
| LogP | 0 |
| SMILES | CC(CC(=O)[O-])O.[Na+] |
| Synonyms | 3-Hydroxybutyric acid sodium |
| HS Tariff Code | 2934.99.9001 |
| Storage |
Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition | Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs) |
Biological Activity
| Targets | Human Endogenous Metabolite |
| ln Vitro | 3-Hydroxybutyric acid sodium (β-Hydroxybutyric acid sodium) is able to interact with lipids (modeled using a DPPC monolayer) and alter phase behavior at clinical concentrations. 3-Hydroxybutyric acid sodium also reduces the interfacial viscosity of DPPC monolayers [1]. |
| References |
[1]. 3-Hydroxybutyric acid interacts with lipid monolayers at concentrations that impair consciousness. Langmuir. 2013 Feb 12;29(6):1948-55. |
Solubility Data
| Solubility (In Vitro) |
H2O : ~25 mg/mL (~198.27 mM; with ultrasonication (<60°C)) DMSO : ~16.67 mg/mL (~132.21 mM; with ultrasonication (<60°C)) |
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 3.25 mg/mL (25.78 mM)(saturation unknown) in 10% DMSO 40% PEG300 5% Tween-80 45% Saline (add these co-solvents sequentially from left to right, and one by one),clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 32.5 mg/mL clear DMSO stock solution and add it to 400 μL PEG300, mix well; then add 50 μL Tween-80 to the above system, mix well; then continue to add 450 μL of normal saline to make up to 1 mL. Preparation of normal saline: Dissolve 0.9 g of sodium chloride in ddH₂O and make up to 100 mL to obtain a clear and transparent normal saline solution. Solubility in Formulation 2: ≥ 3.25 mg/mL (25.78 mM)(saturation unknown) in 10% DMSO 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one),clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 32.5 mg/mL clear DMSO stock solution and add it to 900 μL of 20% SBE-β-CD saline solution and mix well. 2 g SBE-β-CD (sulfobutyl ether β-cyclodextrin) powder is diluted to 10 mL of saline and completely dissolved until clear and transparent. Solubility in Formulation 3: ≥ 3.25 mg/mL (25.78 mM)(saturation unknown) in 10% DMSO 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one),clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 32.5 mg/mL clear DMSO stock solution and add it to 900 μL corn oil and mix well. Solubility in Formulation 4: 100 mg/mL (793.08 mM) in PBS (add these co-solvents sequentially from left to right, and one by one),clear solution;with sonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 32.5 mg/mL clear DMSO stock solution and add it to 900 μL corn oil and mix well. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 7.9308 mL | 39.6542 mL | 79.3084 mL | |
| 5 mM | 1.5862 mL | 7.9308 mL | 15.8617 mL | |
| 10 mM | 0.7931 mL | 3.9654 mL | 7.9308 mL |