3-Amino-4,6-dimethylpyridine (5A-DMP) is a UHRF1 inhibitor that targets the Arg-binding cavity of the UHRF1 TTD domain. 3-Amino-4,6-dimethylpyridine interferes with DNA methylation by blocking the interaction between UHRF1 and LIG1, and can be used in cancer research.

Physicochemical Properties

Molecular Formula	C7H10N2
Molecular Weight	122.17
CAS #	1193-71-1
Appearance	Off-white to yellow solid powder
SMILES	N1C([H])=C(C(C([H])([H])[H])=C([H])C=1C([H])([H])[H])N([H])[H]
Synonyms	5A-DMP
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Structure-based screening combined with computational and biochemical analyses identified the inhibitor targeting the binding of DNA Ligase 1 to UHRF1. Bioorg Med Chem. 2021 Dec 15;52:116500.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	8.1853 mL	40.9266 mL	81.8532 mL
	5 mM	1.6371 mL	8.1853 mL	16.3706 mL
	10 mM	0.8185 mL	4.0927 mL	8.1853 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.