21-Hydroxyeplerenone is the major metabolite of the mineralocorticoid receptor antagonist eplerenone, formed from eplerenone via the cytochrome P450 (CYP) isozyme CYP3A4.

Physicochemical Properties

Molecular Formula	C24H30O7
Molecular Weight	430.49
CAS #	334678-67-0
SMILES	O1[C@@H]2C[C@]3(C)[C@]4(CC(C(=O)O4)O)CC[C@H]3[C@@H]3[C@H](C(=O)OC)CC4=CC(CC[C@]4(C)[C@]132)=O
Synonyms	21-Hydroxyprinone
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.3229 mL	11.6147 mL	23.2293 mL
	5 mM	0.4646 mL	2.3229 mL	4.6459 mL
	10 mM	0.2323 mL	1.1615 mL	2.3229 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.