2′-O-Methylguanosine 5′-monophosphate is a ribosomal nucleotide complex group (pGm), mainly used for DNA coupling. When current antibodies recognize pGm, the elements are arranged in descending order of importance as parent base, methylated ribose moiety and phosphate group. 2′-O-Methylguanosine 5′-monophosphate can also be used to prepare RNA vaccines as a 5'-terminal nucleotide to block RNA molecules.

Physicochemical Properties

Molecular Formula	C11H16N5O8P
Molecular Weight	377.25
CAS #	24121-01-5
SMILES	OP(OCC1OC(N2C=NC3C(NC(=NC2=3)N)=O)C(OC)C1O)(O)=O
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Preparation and specificity of antibodies directed toward the ribose methylated nucleotide, 2'-O-methylguanosine 5'-monophosphate. Biochim Biophys Acta. 1981 Sep 28;655(2):265-7. [2]. A modified structure at the 5'-terminus of mRNA of vaccinia virus. FEBS Lett. 1975 Jan 1;49(3):385-9.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.6508 mL	13.2538 mL	26.5076 mL
	5 mM	0.5302 mL	2.6508 mL	5.3015 mL
	10 mM	0.2651 mL	1.3254 mL	2.6508 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.