2-Methylbiphenyl-oxadiazole-NH-Ph-NH-PEG3-C2-NH-Boc is a PD-L1 ligand-linker polymer for AUTAC PD-L1 degrader-3. 2-Methylbiphenyl-oxadiazole-NH-Ph-NH-PEG3-C2-NH-Boc can be used in AUTAC synthesis.

Physicochemical Properties

Molecular Formula	C35H45N5O6
Molecular Weight	631.76
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Discovery of small molecules for autophagy-lysosome degradation of immune checkpoint proteins. Eur J Med Chem. 2024 Dec 15;280:116958.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.5829 mL	7.9144 mL	15.8288 mL
	5 mM	0.3166 mL	1.5829 mL	3.1658 mL
	10 mM	0.1583 mL	0.7914 mL	1.5829 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.