2-Methylbiphenyl-oxadiazole-NH-Ph-CHO is the PD-L1 ligand of AUTAC PD-L1 degrader-3. 2-Methylbiphenyl-oxadiazole-NH-Ph-CHO can be used in AUTAC synthesis.

Physicochemical Properties

Molecular Formula	C22H17N3O2
Molecular Weight	355.39
CAS #	2766689-18-1
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Discovery of small molecules for autophagy-lysosome degradation of immune checkpoint proteins. Eur J Med Chem. 2024 Dec 15;280:116958.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.8138 mL	14.0691 mL	28.1381 mL
	5 mM	0.5628 mL	2.8138 mL	5.6276 mL
	10 mM	0.2814 mL	1.4069 mL	2.8138 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.