2-Methoxypyrazine is a bioactive compound. 2-Methoxypyrazine may be used in a variety of biochemical studies.

Physicochemical Properties

Molecular Formula	C5H6N2O
Molecular Weight	110.11
Exact Mass	110.048
CAS #	3149-28-8
Related CAS #	2-Methoxypyrazine-d3;32046-21-2
PubChem CID	18467
Appearance	Colorless to light yellow liquid
Density	1.1±0.1 g/cm3
Boiling Point	153.6±0.0 °C at 760 mmHg
Flash Point	45.6±0.0 °C
Vapour Pressure	4.2±0.2 mmHg at 25°C
Index of Refraction	1.495
LogP	0.75
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	1
Heavy Atom Count	8
Complexity	67.4
Defined Atom Stereocenter Count	0
SMILES	COC1=NC=CN=C1
InChi Key	WKSXRWSOSLGSTN-UHFFFAOYSA-N
InChi Code	InChI=1S/C5H6N2O/c1-8-5-4-6-2-3-7-5/h2-4H,1H3
Chemical Name	2-methoxypyrazine
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References	[1]. C Sala, et al. Headspace solid-phase microextraction method for determining 3-alkyl-2-methoxypyrazines in musts by means of polydimethylsiloxane-divinylbenzene fibres. J Chromatogr A. 2000 Jun 2;880(1-2):93-9.
Additional Infomation	Methoxypyrazine is an aromatic ether and a member of pyrazines.

Solubility Data

Solubility (In Vitro)

DMSO: 100 mg/mL (908.18 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (22.70 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (22.70 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.5 mg/mL (22.70 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	9.0818 mL	45.4091 mL	90.8183 mL
	5 mM	1.8164 mL	9.0818 mL	18.1637 mL
	10 mM	0.9082 mL	4.5409 mL	9.0818 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.