6-Chloroguanine is a biochemical compound that may be utilized as a biomaterial or organic/chemical reagent for biomedical research.

Physicochemical Properties

Molecular Formula	C5H4CLN5
Molecular Weight	169.57
Exact Mass	169.015
CAS #	10310-21-1
PubChem CID	5360349
Appearance	Off-white to light yellow solid powder
Density	1.8±0.1 g/cm3
Boiling Point	315.2ºC at 760mmHg
Melting Point	>300 °C(lit.)
Flash Point	144.4ºC
Vapour Pressure	1.75E-15mmHg at 25°C
Index of Refraction	1.827
LogP	-0.03
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	0
Heavy Atom Count	11
Complexity	154
Defined Atom Stereocenter Count	0
InChi Key	RYYIULNRIVUMTQ-UHFFFAOYSA-N
InChi Code	InChI=1S/C5H4ClN5/c6-3-2-4(9-1-8-2)11-5(7)10-3/h1H,(H3,7,8,9,10,11)
Chemical Name	6-chloro-7H-purin-2-amine
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vitro	2-Amino-6-chloropurine is a starting point for the creation of nucleotide analogs that have antiviral properties against the human herpesvirus 6 (HHV-6) and the Epstein-Barr virus (EBV). 11. (Z)- and (E)-2-((hydroxymethyl)cyclopropylidene)methyladenine and -guanine Qiu, Y.-L., Ksebati, MB, Ptak, RG, et al. New nucleotide analogs possessing wide-ranging antiviral efficacy 1998; J. Med. Chemistry 41(1): 10–23
References	[1]. (Z)- and (E)-2-((hydroxymethyl)cyclopropylidene)methyladenine and -guanine. New nucleotide analogues with a broad-spectrum antiviral activityJ. Med. Chem.41(1) 10-23 (1998).
Additional Infomation	6-chloroguanine is an organochlorine compound that is 7H-purin-2-amine substituted by a chloro group at position 6. It is a member of 2-aminopurines and an organochlorine compound.

Solubility Data

Solubility (In Vitro)

DMSO: 33.33 mg/mL (196.56 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (14.74 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	5.8973 mL	29.4863 mL	58.9727 mL
	5 mM	1.1795 mL	5.8973 mL	11.7945 mL
	10 mM	0.5897 mL	2.9486 mL	5.8973 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.