2,4-Dihydroxypyridine (compound 2) is a pyridine derivative that has inhibitory activity against both Topo IIKHIV activity and HIV-1 replication, with pIC50 values of 5.05 and 4.07 for Topo IIKHIV and HIV-1 replication, respectively.

Physicochemical Properties

Molecular Formula	C5H5NO2
Molecular Weight	111.10
CAS #	626-03-9
Appearance	Solid powder
SMILES	O([H])C1C([H])=C([H])N([H])C(C=1[H])=O
Synonyms	2,4-Dihydroxypyridine; 3-Deazauracil
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. HIV-1 associated Topoisomerase IIβ kinase: a potential pharmacological target for viral replication. Curr Pharm Des. 2013;19(26):4776-86.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	9.0009 mL	45.0045 mL	90.0090 mL
	5 mM	1.8002 mL	9.0009 mL	18.0018 mL
	10 mM	0.9001 mL	4.5005 mL	9.0009 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.